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Selected Publications

For the full list, please visit our Google Scholar profile.

Engineering pyrrolysine systems for genetic code expansion
and reprogramming. 

Daniel L. Dunkelmann* and Jason W. Chin*, Chemical Reviews, 124:11008–11062, 2025.

Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism. 

Daniel L. Dunkelmann°, Carlos Piedrafita°, Alexandre Dickson, Kim C. Liu, Thomas S. Elliott, Marc, Fiedler, Dom Bellini, Andrew Zhou, Daniele Cervettini, and Jason W. Chin. Nature, 625:603–610, 2024.

Quintuply orthogonal pyrrolysyl-tRNA synthetase/tRNApyl pairs. 

Adam T. Beattie°, Daniel L. Dunkelmann°, and Jason W. Chin.  Nature Chemistry, 15:948–959, 2023.

A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design. 

Daniel L. Dunkelmann°, Sebastian B. Oehm°, Adam T. Beattie, and Jason W. Chin. Nature Chemistry, 13:1110–1117, 2021.

Engineered triply orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids.

Daniel L. Dunkelmann°, Julian W. Willis°, Adam T. Beattie, and Jason W. Chin. Nature Chemistry, 12:535–544, 2020.

Total synthesis of Escherichia coli with a recoded genome.

Julius Fredens°, Kaihang Wang°, Daniel de la Torre°, Louise F. H. Funke°, Wesley E. Robertson°, Yonka Christova, Tiongsun Chia, Wolfgang H. Schmied, Daniel L. Dunkelmann, Václav Beránek, Chayasith Uttamapinant, Andres Gonzalez Llamazares, Thomas S. Elliott, and Jason W. Chin. Nature, 569:514–518, 2019.

Amide-forming chemical ligation via o-acyl hydroxamic acids.

Daniel L. Dunkelmann°, Yuki Hirata°, Kyle A. Totaro, Daniel T. Cohen, Chi Zhang, Zachary P. Gates, and Bradley L. Pentelute. PNAS, 115:3752–3757, 2018.

Equal contributions are indicated by °; shared corresponding authorships by *.

Google Scholar

Max Planck Institute of Molecular Plant Physiology, Department of Organelle Biology and Biotechnology, Am Mühlenberg 1, 14476 Potsdam, Germany

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